Andreas Ludwig

The paper identifies naturally occurring ACE2 stalk variants that differentially affect soluble ACE2 release and surface expression of B0AT1.

This study shows that iRhom2 deficiency reduces acute lung inflammation in mice by impairing ADAM17-mediated shedding of inflammatory mediators and neutrophil recruitment.

This study develops an in vitro model to assess endothelial dysfunction under inflammatory stress and finds that combined LPS and PBMC exposure significantly impairs endothelial confluence and increases adhesion molecule expression.

This study identifies a phosphorylation-independent 14-3-3 interaction site in iRhom2's N-terminus that regulates ADAM17 activity and shows how mutations in this region cause different pathological outcomes.