Author

Jennifer A. Brain

Fred Hutch Cancer CenterORCID 0000-0001-8590-6255Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1

Frequent Co-Authors

Brian T. DoiD· 1 shared Craig J. ThomasiD· 1 shared David Edward KaplaniD· 1 shared David J. TischfieldiD· 1 shared David O. HollandiD· 1 shared Emma Elizabeth FurthiD· 1 shared Erena Tuzneen Supan· 1 shared G. J. NadolskiiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Brian T. DoORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJul 7, 2026

Cysteine-mediated bortezomib resistance is governed by α-ketoacid availability

Jennifer A. Brain, Sarah M Chang, Maximilian Kobiesa…·Lucas B. Sullivan

This study shows that α-ketoacids enhance the effectiveness of bortezomib by reducing cysteine-mediated detoxification, thereby increasing proteasome inhibition and cytotoxicity.

DOI 10.64898/2026.07.06.736827

humanexperimental assay

𝕏 PostBluesky

Cancer BiologyJHEP ReportsPeer-reviewedNov 8, 2024

Human GM-CSF/IL-3 enhance tumor immune infiltration in humanized HCC patient-derived xenografts

Kelley M. Weinfurtner, David J. Tischfield, George McClung…·Terence P.F. Gade

This study shows that human GM-CSF and IL-3 expression in humanized mice increases immune cell infiltration in HCC tumors, improving the model's resemblance to human disease.

4 citations

humanflow cytometry

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