Vitaly L. Zimyanin

The paper shows that Eg5 organizes antiparallel microtubule bundles in human metaphase spindles through density-driven steric interactions, independent of spindle bipolarity.

The paper identifies KLP-19's role in regulating microtubule length in the C. elegans spindle midzone, impacting spindle dynamics and force transmission during mitosis.

The paper identifies RIG-I-mediated innate immune activation in FUS-ALS spinal motor neurons due to mitochondrial dsRNA accumulation, which can be targeted by JAK-STAT inhibition, offering potential biomarker-driven treatment options.

The paper uses compartment-specific RNA-sequencing to analyze axonal and somatodendritic transcriptomes of FUS-ALS motor neurons, identifying PLK1 upregulation as a protective response to DNA damage.

The paper investigates the relationship between microtubule length and spindle size in C. elegans meiosis, finding a positive correlation and demonstrating the role of microtubule length in determining spindle dimensions.

The paper shows that glycolic acid and D-lactate restore axonal trafficking and DNA damage response in FUS and SOD1-ALS patient-derived motoneurons.

The paper uses live cell imaging to show reduced ATP levels in FUS-ALS motoneurons, linking metabolic changes to disease vulnerability.

This paper shows that asymmetric myosin activation polarizes the Drosophila anterior-posterior axis by recruiting and maintaining Par-1 at the posterior cortex.