Takanobu Tagawa

This paper develops a vesicle-based CRISPR/Cas9 platform for efficient gene knockout in primary human myeloid cells, preserving viability and enabling downstream functional studies.

This study establishes patient-derived KS xenografts that maintain KSHV infection and recapitulate KS tumor gene signatures, enabling analysis of tumor microenvironment cell communications.

This study identifies IFN-induced circRNAs that resist herpesvirus host shutoff and inhibit lytic infection across multiple herpesvirus subfamilies.