Bruno P. Klaholz

The paper shows that SNORA81-guided pseudouridylation at a specific 28S rRNA site influences selective translation and ovarian cancer cell proliferation.

The paper investigates how the Kozak sequence is recognized during eukaryotic translation initiation using cryo-EM structures, revealing an induced-fit mechanism involving conformational changes in mRNA, rRNA, and initiation factors.

The paper identifies RanBP2-dependent annulate lamellae as a distinct pathway for nuclear pore assembly and nuclear expansion in somatic cells.

The paper identifies extended Shine-Dalgarno motifs in S. aureus that govern translation initiation, revealing species-specific mechanisms and regulatory features.

This paper improves 3D cryo-EM reconstructions by explicitly correcting non-uniform distributions of 2D projections using the VUE program.

This study identifies UBAP2L's role in assembling functional nuclear pore complexes at the nuclear envelope by facilitating Y-complex formation and interactions with key nucleoporins.

This study identifies RlmQ, a methyltransferase in Staphylococcus aureus responsible for a unique rRNA modification, and shows its impact on bacterial growth and virulence.

The paper presents a 1.9 Å cryo-EM structure of the human 80S ribosome, revealing new rRNA modifications and ions, and their roles in RNA architecture and function.

The paper introduces new computational tools for validating cryo-EM maps and atomic models, including methods for resolution estimation, map sharpening, and map analysis.

The paper introduces 3DClusterViSu, a method for analyzing 3D SMLM data using Voronoi tessellations, demonstrating its effectiveness on microtubules and histone proteins.