Ottilie von Loeffelholz

The paper investigates how the Kozak sequence is recognized during eukaryotic translation initiation using cryo-EM structures, revealing an induced-fit mechanism involving conformational changes in mRNA, rRNA, and initiation factors.

The paper identifies extended Shine-Dalgarno motifs in S. aureus that govern translation initiation, revealing species-specific mechanisms and regulatory features.

This paper improves 3D cryo-EM reconstructions by explicitly correcting non-uniform distributions of 2D projections using the VUE program.

The paper presents a 1.9 Å cryo-EM structure of the human 80S ribosome, revealing new rRNA modifications and ions, and their roles in RNA architecture and function.