Xiaolei Su

The paper shows macrophages remove protein aggregates from other cells via trogocytosis, driven by lysosomal stress and tmCSF1 signaling.

This study identifies mast cell extracellular granules as bioactive condensates formed by heparin and polyamines, enhancing enzymatic activity and cytokine bioactivity.

CSF1R-CAR T cells induce CSF1R signaling in THP1 cells, promoting their growth, highlighting an unintended effect of CAR therapy.

This study shows that adding intrinsically disordered regions (IDRs) to CARs improves their cytotoxicity against low-antigen cancers by enhancing signaling and killing activity.

This study identifies hyperactive PLCG1 mutations in T-cell leukemia/lymphoma that drive non-canonical signaling, enhancing cell survival and drug resistance.

This study shows that T cell protrusions enable rapid and localized initiation of CAR signaling by facilitating dynamic rearrangement of key signaling molecules.

This study investigates how the inclusion of the ζ-chain affects phosphotyrosine signaling in CD19-CAR T cells using phosphoproteomics and inhibitor experiments.

The paper introduces GIN, a resource that decodes molecular grammars of human intrinsically disordered regions (IDRs) and identifies their functional roles in biological processes and disease.