Francesca Bottanelli

This study investigates the role of AP-1 clathrin adaptor in recycling trans-Golgi network proteins, showing it maintains these proteins in the Golgi during maturation.

This study identifies ARF-1 as a regulator of cargo sorting at FERARI-dependent endosomal recycling hubs through its cycling between active and inactive states.

This study investigates the role of GGAs in AP-1-dependent trafficking using CRISPR-Cas9 and live-cell imaging, finding GGAs modulate bi-directional trafficking by preventing AP-1 cargo retrieval.

This study shows that T cell protrusions enable rapid and localized initiation of CAR signaling by facilitating dynamic rearrangement of key signaling molecules.

The paper identifies two functionally distinct ARF1 compartments involved in post-Golgi sorting and endocytic recycling, challenging the classical vesicle shuttling model.

This paper introduces recombinant biosensors with SNAP tags for multiplex and super-resolution imaging of all 8 phosphoinositides in fixed cells and tissues.

This paper develops SNAP-PROTACs to induce degradation of SNAP-fusion proteins, enabling selective depletion and functional analysis of target proteins.

This study uses live-cell imaging to show ER-to-Golgi transport occurs via a dynamic ARF4 tubular-vesicular network connected to the ER and Golgi.