Nathan W. Goehring

This paper shows that a minimal mechanical model of an actomyosin network can spontaneously polarize and move through balanced contractility and adhesion, without external cues or complex signaling.

The paper shows that PAR-3 proteins form stable clusters during anoxia in C. elegens embryos, preserving polarity information for rapid reactivation after metabolic arrest.

This paper shows that cell cycle oscillations in a polarity network allow cells to switch polarity states in response to morphogenetic cues by modulating feedback and stability.

This study shows that targeting drug-sensitive cancer cells with G12Ci inhibitors and combining it with immune therapies can eliminate drug-resistant subclones through immune-mediated bystander killing.

This study shows that optimized dimerization of the PAR-2 RING domain enables cooperative and selective membrane recruitment, enhancing robustness and responsiveness in cell polarization.

The paper shows that nonlinear spatial cue readout in C. elegans zygotes ensures robust asymmetric cell division despite input variation.