Nguyễn Thụy Thương Thương

This study examines drug response patterns in diverse Mycobacterium tuberculosis strains to combination therapy, finding that strain-specific sensitivity varies more than genetic distance.

This study compares long-read and short-read sequencing for tuberculosis drug resistance and outbreak analysis, finding they are comparable with minimal differences in key clinical outputs.

This study identifies a 1,093-gene module associated with Mtb burden in PTB, driven by neutrophils and monocytes, and highlights CNIH4 as a key predictor of bacterial burden.

The paper identifies variants in Mycobacterium tuberculosis associated with decreased virulence gene expression and increased transmissibility, particularly in drug-resistant strains.

This study uses scRNA-seq to analyze CSF and blood from TBM patients, identifying inflammatory cell subtypes and altered metabolic pathways in CSF.

This study shows that Mycobacterium tuberculosis adapts to acidic conditions by increasing growth-arrested cells, which enhance drug tolerance and survival.

This study identifies gene modules, hubs, and pathways associated with TBM mortality using whole blood RNA sequencing and develops a 4-gene biomarker for predicting death from TBM.

This study examines rifampicin tolerance in isoniazid-resistant Mycobacterium tuberculosis isolates, finding increased tolerance and faster growth in resistant strains, which may contribute to multidrug-resistant TB emergence.

This study quantifies antibiotic resistance in tuberculosis using genomic data and MIC measurements to identify genetic determinants of resistance and hypersensitivity across multiple drugs.

The paper uses Bayesian analysis to show the LTA4H TT genotype improves survival in TBM patients in Vietnam and Indonesia, but only when disease severity is not the primary cause of mortality.