Yan Hu

This study shows that Siglec-F protects against elastase-induced lung inflammation and emphysema by regulating airspace macrophages in mice.

The paper shows that the epigenetic state of the cell of origin influences susceptibility to Tet2 mutation, with Sox4 promoting dedifferentiation and increased clonal output in hematopoietic stem cells.

The paper develops an antigen-specific assay for T cell exhaustion and identifies IKAROS as a driver of exhaustion, showing that iberdomide prevents exhaustion by blocking chromatin remodeling.

The paper introduces PRINT, a deep learning method to correct chromatin accessibility data and analyze DNA-protein interactions, revealing structural and functional changes in cis-regulatory elements during hematopoiesis and aging.

This paper develops FigR, a framework to integrate scATAC-seq and scRNA-seq data to infer gene regulatory networks and identify TF regulators in immune responses.

The paper introduces SHARE-seq, a method to profile RNA and chromatin in single cells, and identifies DORCs that predict lineage commitment by chromatin accessibility changes.

This study investigates telomere maintenance in fission yeast lacking telomerase, showing that TERRA RNA and shelterin component changes support recombination-based telomere maintenance.

This paper develops a high-throughput sequencing method to analyze telomere sequences in S. pombe, revealing repeat module correlations and telomere length-dependent preferences.