Lucie Carrier

This study identifies VASH1 phosphorylation by PRKG1 as a mechanism regulating tubulin detyrosination in DRG neurons through CNP signaling.

This study shows that myosin inhibition with mavacamten is effective in treating HCM caused by both truncating and missense variants in MYBPC3, despite different pathomechanisms.

This study shows ruxolitinib reduces CRYAB p.Arg120Gly protein aggregates in DRM models by enhancing the ubiquitin-proteasome system.

This study shows that mitochondrial reactive oxygen species contribute to arrhythmias in hypertrophic cardiomyopathy by disrupting calcium handling and electrical conduction.

The paper uses imaging to show that sarcomere proteins are replaced by newly translated ones, disproving the existing protein pool model and revealing a unidirectional replacement mechanism.