Dennis Lee Kasper

This study identifies BfaGC, a sphingolipid produced by Bacteroides fragilis, that facilitates neonatal colonization and immune modulation through metabolic adaptation.

The paper creates a spectral library of N-acyl lipids from metabolomics data, identifies novel compounds, and links them to health conditions like HIV and cognitive impairment.

This study uses top-down mass spectrometry to determine the detailed structure of B. fragilis lipooligosaccharide, revealing its poly-galactose-rhamnose-KDO-lipid A architecture and modifications.

This study shows that bacterial sphingolipids worsen colitis by reducing IL-22 production from ILC3 cells in mice.