Marco Molari

The paper develops a stochastic model for affinity maturation and identifies an optimal antigen-concentration protocol that maximizes the probability of reaching a target antibody affinity.

This study identifies how the intestinal microbiota drives the evolution of pathoadaptive traits in ESBL E. coli through adhesion and biofilm formation.

This study identifies ISL3 elements as drivers of rapid genomic evolution in E. faecium, enabling metabolic adaptation in clinical settings through structural variation and gene regulation.

This study shows that phenotypic heterogeneity in bacteria affects phage-bacteria coevolution, leading to phage extinction due to genetic resistance evolution in the intestinal tract.

The paper analyzes the evolution of 3425 actinobacteriophage genomes, finding conserved synteny and varying linkage decay patterns due to homologous recombination.

The paper introduces Aionostat, an automated device for high-throughput bacteriophage evolution studies, demonstrating its ability to accelerate and standardize phage adaptation and recombination experiments.

The paper analyzes genome evolution in closely related E. coli ST131 strains, finding more accessory genome structural changes than core genome mutations, with most structural changes being short-lived and deleterious.

PanGraph constructs a scalable pan-genome graph from whole-genome assemblies to capture structural and nucleotide polymorphisms across bacterial populations.