Karim P. M. Labib

The paper shows that MCM10 and SLD-2/RECQL4 are required for helicase activation in metazoan DNA replication, with mutations in these factors linked to human disease.

The paper identifies TTF2 as a regulator that couples TRAIP to Pol epsilon, enabling TRAIP to ubiquitylate the CMG helicase and drive replisome disassembly and MiDAS during mitosis.

This study identifies USP37's role in protecting mammalian cells from DNA replication stress by counteracting ubiquitylation of the CMG helicase by CUL2LRR1 and TRAIP.

This study shows that CMG helicase disassembly is essential in budding yeast and occurs via two pathways involving ubiquitylation and Rrm3/Pif1 helicases.

This study identifies TOM20, TOM70, TOM40, and associated subunits as critical for PINK1 activation in a reconstituted yeast system, providing insights for PINK1 activator development.

This study identifies DONSON as essential for CDC45-MCM-GINS helicase assembly during S-phase, linking it to Meier-Gorlin Syndrome.

The paper shows that UBX proteins lower the ubiquitin threshold for p97-UFD1-NPL4 to unfold substrates, similar to yeast.