James Sáenz

This study uses calorimetry to show how lipidome changes affect metabolic efficiency and growth in JCVI-Syn3B cells, revealing lipid-dependent entropic costs of division.

The paper develops a new expression system for WR806 to study Cas1 in DNA repair, showing improved protein expression control and revealing dose-dependent mobility changes in Cas1 after UV damage.

This study investigates how lipid membranes affect the activity and stability of natural and artificial ribozymes, showing that different lipid phases can enhance or reduce catalytic activity and RNA degradation.

This study shows that a minimal cell membrane with two lipid species can support life, highlighting the importance of acyl chain diversity over head group diversity.

The paper uses chemically defined lipid diets to study how lipidome complexity affects membrane function and cell phenotypes in minimal cells.

This study analyzes lipidome adaptation in Mycoplasma mycoides and its minimal cell JCVI-Syn3B under temperature changes, revealing universal patterns and constraints in lipid remodeling.

This study shows that hopanoids and sterols modulate lipid ordering differently based on phospholipid acyl chain unsaturation position, with cholesterol providing broader ordering effects than diplopterols.