Kristine Henriksen

This paper shows that long-term cytokine exposure impairs alpha-cell glucagon secretion in human islet microtissues, which is partially restored by dual incretin receptor agonists.

This study investigates the functional, protective, and transcriptomic effects of GIP on cytokine-exposed human pancreatic islets and EndoC-βH5 cells, finding CaMK2-dependent insulinotropic effects but limited cytoprotection and transcriptomic modulation.

This paper challenges the dogma that beta-cell death in T1D is primarily apoptotic by presenting evidence for pyroptosis as a key mechanism driving islet inflammation and beta-cell demise.