Feng Tian

This study shows that Dsn1 and Ndc80 are essential for postmitotic neuron survival, distinct from their role in synaptogenesis, and identifies domain-specific functions in neuronal viability.

This study shows that OPTN dysfunction leads to neuroinflammation and RGC death in glaucoma, independent of IOP, and identifies OPTN-NPY signaling as a potential therapeutic target.

This paper develops a biologically inspired microbead platform for inducing chronic ocular hypertension in mice, leading to retinal ganglion cell loss and visual pathway impairment.

The paper identifies four ATF/CEBP transcription factors that drive injury-induced neurodegeneration of retinal ganglion cells and shows their role in glaucoma.

The paper identifies transcriptional programs that enhance survival and axon regeneration of injured retinal ganglion cells using single-cell transcriptomics and computational analysis.