Xavier Charpentier

This study identifies two D-loop resolution systems in bacteria, YraN/ComM and CoiA/RadA, that work together to process the transformation D-loop during natural genetic transformation.

This study identifies three novel immune systems in bacteria that protect against conjugative plasmids, revealing their role in limiting plasmid spread and highlighting the evolutionary arms race between bacteria and plasmids.

This study shows that mobile genetic elements in bacteria generate antibiotic persistence traits through heterogeneous chromosomal excision, enhancing survival under antibiotic treatment.

This paper identifies calcium as a key inducer of natural transformation in Acinetobacter baumannii, revealing both transcriptional and structural mechanisms by which calcium activates type IV pilus function.

The paper quantifies the role of natural transformation in gene acquisition in bacteria, finding it contributes to a small percentage of novel genes but potentially includes high-impact antibiotic resistance genes.

This study examines genetic and phenotypic changes in Acinetobacter baumannii during a five-year UTI without antibiotic treatment, revealing genome reduction and loss of adhesion capacity but conserved colistin resistance.

This study investigates how the Xer recombination system in Acinetobacter baumannii facilitates plasmid co-integration and gene exchange, contributing to the spread of antibiotic resistance.

The paper quantifies transformation rates in bacterial pathogens and links them to intragenomic conflicts with mobile genetic elements, showing similar evolutionary trends across species.

This study shows AbaR-type islands persist in Acinetobacter baumannii by integrating into comM, reducing their removal while allowing continued genetic exchange.