ImmunologyPLoS PathogensPeer-reviewed
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Disruption of riboflavin biosynthesis in mycobacteria establishes 5-amino-6-D-ribitylaminouracil (5-A-RU) as key precursor of MAIT cell agonists
Melissa Dalcina Chengalroyen, Nurudeen Oketade, Aneta H. Worley…·David Michael Lewinsohn
Deleting early riboflavin genes (ribA2 in both species, ribG in M. smegmatis) sharply reduced MAIT cell activation, while ribH deletion raised recognition of M. tuberculosis only.
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