Amy Hauck Newman

The paper analyzes bitopic ligands for dopamine D2 and D3 receptors, showing that linker structure and stereochemistry significantly influence transducer bias profiles.

The paper investigates how a subtle structural change in modafinil analogs affects their binding to the dopamine transporter, revealing conformational differences between sulfoxide and sulfide substitutions.

The paper develops pharmacological tools to selectively target central versus peripheral dopamine D2-like receptors and shows their distinct roles in treating dysglycemia.

The paper identifies two disruptive SERT variants in treatment-resistant affective disorder patients and shows they cause partial loss-of-function, with one variant responsive to pharmacochaperoning.

The paper uses super-resolution microscopy to show that dopamine transporter (DAT) in neurons exists in dynamic nanodomain and unclustered configurations, regulated by excitatory drive and D2-autoreceptor activity.

The paper demonstrates fast synaptic-like transmission from striatal cholinergic interneurons to dopaminergic axons, showing axonal integration of synaptic input into spiking.

The paper identifies a dominant-negative DAT variant linked to parkinsonism and neuropsychiatric disease through functional and in vivo studies.

This study examines how the D3R antagonist PG01037 affects morphine-induced behaviors in mice, finding it reduces hyperlocomotion and antinociception but not locomotor sensitization or catalepsy.