Hanah M. Georges

This study shows methadone induces sterile inflammation in fetal membranes via TLR7, TLR8, NLRP3, opioid receptors, and NFκB/MAPK signaling in both human and mouse models.

The paper shows that miR-146a-3p in small extracellular vesicles from viral-stimulated fetal membranes activates TLR7/8 to drive inflammation.

This study shows buprenorphine induces sterile inflammation in human fetal membranes, increasing preterm birth risk via TLR4, NLRP3, and MAPK pathways.

This study identifies miR-146a-3p as a TLR8-activating microRNA that contributes to fetal membrane inflammation and preterm birth in response to bacterial LPS.