Katarzyna M. Tych

The paper identifies a shared topological organisation in divergent arenavirus intergenic RNAs using graph theory and structural analysis.

This study uses single-molecule force spectroscopy and molecular dynamics to analyze the unfolding and folding of double-knotted and single-knotted proteins, revealing that double-knotted proteins require chaperone assistance for full knotting.

This paper develops a one-pot dual protein labelling method using orthogonal reactions to enable simultaneous mechanical and fluorescent readouts in optical tweezers for studying protein conformational dynamics.

This paper demonstrates hybrid polymer-lipid membranes that enable stable nanopore sensing in human serum, showing native-like nanopore behavior and efficient analyte sampling.

The paper investigates how ligand-induced oligomer dissociation affects enzyme diffusion using mass photometry, finding substrate-induced dissociation in some enzymes and not others.

This study investigates protein translocation through nanopores, finding that blob-like structures form during transport, and identifies conditions for single-file transport.

The paper uses single-molecule optical tweezers to study the dynamics and interdomain interactions of the ABC transporter OpuA in lipid nanodiscs.

This study uses biophysical methods to show that autophosphorylation inhibits LRRK2 dimerization, suggesting it as a negative regulator with implications for Parkinson's disease.