Xiaojuan Zhang

This study identifies a kinase-dependent negative feedback mechanism regulating LRRK2 Roc G domain activity through autophosphorylation of T1343, affecting GTP hydrolysis kinetics.

This study uses biophysical methods to show that autophosphorylation inhibits LRRK2 dimerization, suggesting it as a negative regulator with implications for Parkinson's disease.

This study shows that DNA 5-methylcytosine methylation reduces G-quadruplex formation, affecting gene transcription and linking epigenetic regulation to genome structure.