Jeanne Chiaravalli

This paper develops a deep learning model to identify drug modes of action from high-throughput images of chemically and genetically perturbed Corynebacteria.

This paper uses deep learning to identify antibiotic modes of action from brightfield images without fluorescent labeling, achieving high accuracy in detecting drug exposure and novel mechanisms.

This study designs peptides targeting the FtsQBL divisome complex in E. coli using structure-guided methods, showing they inhibit cell division.

This paper develops a single domain antibody targeting ACE2 that protects against SARS-CoV-2 infection in mice when delivered intranasally.

This study uses high-throughput screening to identify small molecule inhibitors that block coronavirus entry, finding a novel broad-spectrum antiviral.

The paper identifies a small-molecule inhibitor of Lats kinases that promotes Yap-dependent proliferation in postmitotic mammalian tissues, enabling hair cell regeneration in the inner ear.