Elisabeth P. Carpenter

This study presents cryoEM structures of TASK-1 and TASK-3 channels, revealing structural insights into their gating mechanism and pH sensitivity, and how mutations disrupt function in disease.

This study determines the structural mechanism of CerS6, a ceramide synthase, using cryo-EM and biochemical analysis, revealing a ping-pong reaction mechanism and insights into fumonisin B1 inhibition.

The paper identifies nanobodies that selectively modulate TREK-2 channel activity and reveals their binding mechanisms through structural analysis.

The paper identifies de novo gain-of-function mutations in KCNK3 causing a developmental disorder with sleep apnea by disrupting X-gating of TASK-1 channels.

This paper reveals the structure of TASK-1 channels, identifying a unique lower X-gate that traps inhibitors in the vestibule, explaining their slow washout and pharmacological properties.