Author
Ashley C. W. Pike
University of OxfordORCID 0000-0001-9661-2607Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2019-2026 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 31 mutual co-author links5 papers
Recent·Most cited
- NeurosciencebioRxivPreprint
Structures of the human adult muscle-type nicotinic receptor in resting and desensitised states
Anna Li, Ashley C. W. Pike, Richard G. Webster…·Yin Yao Dong
The paper presents structures of human adult muscle-type nicotinic receptors in resting and desensitised states and examines the effects of genetic variants on channel function.
DOI 10.1101/2024.12.13.624530 - BiochemistryNature Structural & Molecular BiologyPeer-reviewed
Structural basis of the mechanism and inhibition of a human ceramide synthase
Tomas C. Pascoa, Ashley C. W. Pike, Christofer S. Tautermann…·David Bryant Sauer
This study determines the structural mechanism of CerS6, a ceramide synthase, using cryo-EM and biochemical analysis, revealing a ping-pong reaction mechanism and insights into fumonisin B1 inhibition.
29 citations - BiophysicsNature CommunicationsPeer-reviewed
Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation
Karin E. J. Rödström, Alexander Cloake, Janina Sörmann…·Stephen J. Tucker
The paper identifies nanobodies that selectively modulate TREK-2 channel activity and reveals their binding mechanisms through structural analysis.
15 citations - Molecular BiologybioRxivPreprint
A unique lower X-gate in TASK channels traps inhibitors within the vestibule
Karin E. J. Rödström, Aytuğ K. Kiper, Wei Zhang…·Elisabeth P. Carpenter
This paper reveals the structure of TASK-1 channels, identifying a unique lower X-gate that traps inhibitors in the vestibule, explaining their slow washout and pharmacological properties.