Robert A. Edwards

This study identifies a conserved CD74+ macrophage niche driven by MIF-CD74 signaling that supports multi-organ metastasis in breast cancer and shows its therapeutic targeting reduces metastatic burden.

This study infects 5xFAD mice with SARS-CoV-2 and finds no change in Alzheimer's pathology but widespread gene expression changes in multiple cell types.

This study identifies LNM cells as a pre-malignant state in melanoma initiation, showing they pre-exist in normal skin, expand with Braf activation, and contribute to drug resistance.

The paper isolates and characterizes two colorectal cancer stem cell subtypes, showing they create distinct tumor microenvironments and unify existing CRC classifications.

This paper constructs a comprehensive spatially resolved single-cell genomic atlas of the adult human breast, identifying 11 major cell types and revealing diverse immune and epithelial cell populations.

This paper designs a CDC42 effector interaction inhibitor (ARN22089) that shows anti-cancer activity by blocking tumor invasion and angiogenesis.