Patricia Benites Goncalves da Silva

This study shows that Eomes regulates UBC differentiation and migration in mice, mirroring human UBC development, and highlights conserved molecular mechanisms in cerebellar development.

The paper investigates sex bias in medulloblastoma by analyzing multi-omics data and mouse models, finding that testosterone drives male predominance in this tumor.

The paper uses single-cell technologies to show that large-scale chromosomal aberrations drive medulloblastoma initiation, while single-gene oncogenic events like MYC contribute to progression and therapy resistance.

This study shows that loss of Elp1 in cerebellar granule cell progenitors causes ataxia and cerebellar defects in mice, suggesting a role for ELP1 in FD pathogenesis.

This study identifies cell-state plasticity as a driver of heterogeneity in Group 3/4 medulloblastomas, showing that transcription factor perturbation can redirect tumor cells along different differentiation trajectories.