Farah Kobaisi

This study identifies a type I interferon signaling signature in XPC-deficient keratinocytes, linking UVB exposure to JAK/STAT pathway dysregulation and hypersensitivity.

This study shows that IFN-α increases HLA-B-restricted antigen presentation in pancreatic β-cells, potentially influencing T1D pathogenesis.

This paper generates and characterizes CRISPR-Cas9-mediated XPC gene knockout in human skin cells to model XP-C disease and study its phenotypes and molecular mechanisms.

The paper identifies PIK3C3 downregulation as a potential therapeutic strategy to alleviate the photosensitive and DNA repair defects in XPC patients.