Wataru Akahata

This study uses an alphavirus replicon particle expressing IL-12 to reprogram immunosuppressive tumor-associated macrophages and neutrophils, enhancing anti-tumor immunity and reducing tumor growth in mouse models.

A tetravalent dengue VLP vaccine induces neutralizing antibodies and reduces viral replication in non-human primates without ADE.

This study shows that incorporating 5-methylcytidine into saRNA vaccines reduces innate immune activation and adverse effects while maintaining strong immune responses.