Wei He

The paper shows Ufd1's UT3 domain unfolds ubiquitin in an ATP-independent manner, enabling Cdc48/p97 to process polyubiquitinated substrates.

MFPLI evaluates protein-ligand binding authenticity using deep learning with physicochemical and structural features, achieving high accuracy in distinguishing native conformations from docking poses.

This study analyzes TCR repertoires in RA patients and identifies clonal expansion and shared repertoires between EMT and Th17 cells, correlating TCR diversity with disease activity.