MicrobiologyPLoS ONEPeer-reviewed
The heme precursor 5-aminolevulinic acid triggers the shutdown of the HemKR signalling system in Leptospira
Juan Andrés Imelio, Felipe Trajtenberg, Sonia Mondino…·Alejandro Buschiazzo
This study shows that 5-aminolevulinic acid triggers shutdown of the HemKR signaling system in Leptospira by promoting HemK phosphatase activity, leading to gene expression changes and iron-deficit tolerance.