Alejandro Buschiazzo

This study reveals how core-sheath coupling in Leptospira flagella controls curvature and motility, showing its importance in viscous environments and infection.

This study identifies L. pneumophila's LpDot1 protein as a bacterial effector that modifies SFPQ, disrupting paraspeckle organization and host splicing, leading to alternative splice variants of infection-related genes.

The paper demonstrates that reprogramming phosphoryl flow directionality in bacterial phosphorelay systems can generate different dynamic responses, enabling programmable signaling dynamics.

This study shows that 5-aminolevulinic acid triggers shutdown of the HemKR signaling system in Leptospira by promoting HemK phosphatase activity, leading to gene expression changes and iron-deficit tolerance.