NeurosciencebioRxivPreprint
Pathological changes induced by Alzheimer's brain inoculation in amyloid-beta plaque bearing mice
Suzanne Lam, Anne‐Sophie Hérard, Susana Boluda…·Marc Dhénain
This study shows that injecting human Alzheimer's brain extracts into mice with amyloid-beta plaques induces tau pathology, memory deficits, and synaptic loss, with neuritic plaques linked to synaptic impairment.
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