Gilles Bonvento

This study uses an AAV model to show that aggregation-prone tau variants spread more extensively in the mouse brain, suggesting extracellular vesicles may contribute to tau propagation.

This study shows that a L-serine-enriched diet improves adult neurogenesis in 3xTg-AD mice without affecting amyloidosis.

This study identifies Pfkfb3 as essential for astrocytic glycolysis, which preserves cognition by reducing mitochondrial efficiency and redirecting pyruvate to neurons.

The paper shows lactate-dependent glycolysis shifts produce D-serine, linking astrocyte metabolism to synaptic and cognitive functions through CB1 receptor activation.

This study shows that activating the JAK2-STAT3 pathway in astrocytes reduces mutant Huntingtin aggregates and improves disease outcomes in Huntington's disease models.

This study investigates the role of reactive astrocytes in Alzheimer's disease by modulating the JAK2-STAT3 pathway in 3xTg-AD mice, finding no effect on Tau or amyloid pathology but behavioral changes.

This study uses diffusion-weighted magnetic resonance spectroscopy to detect astrocyte reactivity in mice by analyzing changes in myo-inositol diffusion linked to morphological alterations.