Gianluca Grenci

The paper introduces Microdomes, a 3D biology platform that enables shear-free handling and full-spectrum optical imaging of spheroids and organoids.

This study shows curvature guides chiral organization and myogenic differentiation in myoblast tissues, with handedness determined by substrate curvature.

This paper accelerates fluorescence lifetime imaging (FLIM) using single-objective light-sheet microscopy, achieving faster and less phototoxic imaging of live multicellular systems.

This study identifies fibrillar adhesions as the primary integrin complexes that respond to matrix topography, forming independently of focal adhesions.

The paper identifies a Ca2+-dependent mechanism for plasma membrane expansion during hypoosmotic swelling in fission yeast, involving mechanosensitive channels, lipid transfer, and exocytosis.

This paper introduces a pipeline for 3D organoid analysis using multilevel segmentation and cellular topology to quantify morphology and topology changes under various stress conditions.

This study introduces a new method to measure energy dissipation during cell-cell junction rupture and shows that cortical tension and shape relaxation time determine whether junctions behave ductile or brittle.

This study shows that extracellular matrix deposition patterns influence early differentiation in human cardiac gastruloids by shaping spatial organization and cell behavior.