Ikuko Koyama‐Honda

This study investigates ATG gene duplication in vertebrates, showing that most ATG genes were duplicated via whole-genome events near the vertebrate root and explores functional divergence patterns among paralogs.

This study identifies LAMP2B as a mediator of microlipophagy, showing its role in preventing obesity and related metabolic disorders through enhanced lipid hydrolysis.

This paper develops optogenetic tools to induce membrane rupture of specific organelles using engineered BAX proteins with light-sensitive domains.

The paper introduces a multi-parametric particle-based method to analyze organelle landscapes, enabling visualization of heterogeneous organelle structures and transitional states using fluorescence microscopy and UMAP.

The paper shows that STX17 recruitment to mature autophagosomes is temporally regulated by PI4P-driven changes in membrane charge.

The paper identifies a novel phosphorylation of Rab29 at Ser185, mediated by PKC, which regulates its localization and lysosomal stress response in conjunction with LRRK2.