Samuel Huber

This study shows that RYR1 in CD4+ T cells is not essential for their pathogenicity in intestinal inflammation models despite affecting calcium signaling.

The paper shows mitochondrial dysfunction in intestinal epithelium leads to microbiota-dependent injury and identifies gene signatures that distinguish active from inactive inflammation in IBD.

This study uses longitudinal scRNA-seq data from a mouse colitis model to build ODE-based models of immune dynamics, validating predictions with flow cytometry and human IBD gene expression data.

DISCERN improves cell clustering and subtype detection by reconstructing missing gene expression, identifying novel T cell types in COVID-19 and predicting disease severity.