Mingjie Zhang

This study investigates how protein condensates transition from liquid-like to networked states through tunable interactions, revealing critical behavior and percolation transitions linked to biological function.

The paper identifies and characterizes a fourth type VI secretion system (H4-T6SS) in Pseudomonas aeruginosa, showing it is repressor-gated and contributes to inter- and intraspecific antagonism.

This study determines the molecular mechanism of enfumafungin inhibition and resistance in Candida glabrata FKS1 using cryo-EM and functional analyses.

This study presents the cryo-EM structure of DISC1, revealing its homotetrameric architecture and its ability to bind multiple partner proteins.

This study shows that RIBEYE forms dynamic synaptic ribbon structures through phase transition and phase separation, enabling structural plasticity in response to physiological signals.

This study identifies Fha as the initiator of T6SS assembly in Acidovorax citrulli, showing it forms LLPS condensates that recruit T6SS components, revealing an inside-first assembly model.

This study identifies ERM proteins as regulators of EPJ shape and number in neurons through actin bundling and phase separation.

This study identifies CDKL5 as a regulator of synaptic structural plasticity through liquid-liquid phase separation, linking its dysfunction to CDKL5 deficiency disorder.

The paper identifies ASAP1 as a specific binder of gAnkB, revealing structural and functional insights into their interaction and potential roles in axonal cytoskeleton regulation.

This study identifies that CaMKII autophosphorylation and binding to GluN2B are necessary for synaptic memory, while kinase activity is not required.

The paper shows that CaMKII activation leads to persistent liquid-liquid phase separation with GluN2B, forming stable postsynaptic assemblies that enhance synaptic transmission and memory formation.

This study shows that ankyrin-G regulates forebrain connectivity and network synchronization through its interaction with GABARAP, and identifies a variant linked to bipolar disorder.