Author

Isabella Santi

University of BaselORCID 0000-0001-9408-1793Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:proteomics· 2 Organism:bacteria (other)· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Hector Arturo Hernandez GonzaleziD· 2 shared Nicola ZamboniiD· 2 shared Pablo ManfrediiD· 2 shared Simon van VlietiD· 2 shared Urs JenaliD· 2 shared Alexander KlotziD· 1 shared Alexander SchmidtiD· 1 shared Andreas KaczmarczykiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersMicrobiology

Hector Arturo Hernandez GonzalezORCID

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintOct 24, 2025

Coenzyme A depletion causes antibiotic tolerance in Pseudomonas aeruginosa

Pablo Manfredi, Isabella Santi, Enea Maffei…·Urs Jenal

This study identifies coenzyme A depletion as a cause of antibiotic tolerance in Pseudomonas aeruginosa using proteomic, metabolomic, and machine learning analyses.

3 citations

bacteria (other)proteomics

𝕏 PostBluesky

MicrobiologyThe EMBO JournalPeer-reviewedSep 25, 2024

Toxin-mediated depletion of nicotinamide dinucleotides drives persister formation in a human pathogen

Isabella Santi, Raphael Dias Teixeira, Pablo Manfredi…·Urs Jenal

This study shows that the RES domain TA system in P. aeruginosa promotes persister formation by depleting NAD and NADP under nutrient stress, enhancing bacterial survival during antibiotic treatment.

10 citations

humanproteomics

𝕏 PostBluesky