Pablo Manfredi

This study identifies how the intestinal microbiota drives the evolution of pathoadaptive traits in ESBL E. coli through adhesion and biofilm formation.

This study identifies coenzyme A depletion as a cause of antibiotic tolerance in Pseudomonas aeruginosa using proteomic, metabolomic, and machine learning analyses.

The paper uses CRISPRi screens to identify metabolic vulnerabilities in P. aeruginosa PAO1 under different conditions, revealing key genes for targeting chronic infections.

This study shows that the RES domain TA system in P. aeruginosa promotes persister formation by depleting NAD and NADP under nutrient stress, enhancing bacterial survival during antibiotic treatment.

This study shows Pseudomonas aeruginosa breaches lung epithelia by invading goblet cells, using T6SS for invasion and T3SS for cell death, leading to barrier rupture and infection spread.