Michael Peter Barrett

This study uses spatial transcriptomics to map immune responses in Atlantic salmon gills infected with AGD, revealing region-specific transcriptional domains and immune organization.

The paper uses a five-layer systems analysis to show that protein degradation, not genomic changes, drives stage differentiation in Leishmania parasites.

This study identifies glycerol as a trigger for Trypanosoma brucei differentiation into transmissible forms under tissue-like conditions, challenging the traditional bloodstream model of transmission.

The paper identifies persister-like cells in Leishmania that survive antimony treatment and show cross-tolerance to other drugs.

This study compares lipidomic profiles of Trypanosoma congolense and Trypanosoma brucei to understand their metabolic differences and implications for in vitro culture and therapy development.

This paper develops a CRISPR base-editing library for genome-wide loss-of-function screening in Leishmania mexicana to study drug response mechanisms and identify novel biomarkers.

This study identifies factors contributing to trypanocide failure in cattle with African animal trypanosomosis in Tanzania, finding drug quality, improper use, and resistance as key issues.

This paper shows that OvoA, an enzyme involved in ovothiol synthesis in Leishmania mexicana, is not essential for growth or infectivity but affects sensitivity to amphotericin B.

This study aligns metabolomics LC-MS datasets from malaria, leishmaniasis, and Zika virus to identify fever-associated metabolites, finding the kynurenine pathway as most affected.

The paper quantifies transcriptome and metabolome changes in Leishmania during quiescence induced by drug pressure or stationary phase, revealing global transcriptional reduction and specific upregulation of membrane and autophagy-related genes.