Author

Shyam Sundhar Bale

Scribe Therapeutics;ORCID 0000-0001-9590-8553Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:CRISPR screen· 1 Organism:mouse· 1 Organism:non-human primate· 1

Frequent Co-Authors

Ross White· 2 shared Addison V Wright· 1 shared Allison Didychuk· 1 shared Amanda MokiD· 1 shared Anna MrakiD· 1 shared Ashley E Graham· 1 shared Ashley T WongiD· 1 shared Beatriz AlvaradoiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMolecular Biology

Ross White

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintNov 12, 2026

Comprehensive engineering of the CasX-Editor to generate a therapeutically optimized genome editor

Addison V Wright, Sean A Higgins, Elizabeth J Bailey…·Benjamin L Oakes

This paper engineers the CasX-Editor to create a more potent and specific genome editor for therapeutic use, showing improved activity and reduced off-target effects in nonhuman primates.

DOI 10.64898/2026.11.10.765514

non-human primateexperimental assay

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Molecular BiologybioRxivPreprintAug 31, 2026

Sequential Proofreading Enhances Specificity and Potency of CRISPR-CasX-based Epigenetic Repressors

Emeric J. Charles, Ross White, Ryan V. Tran…·Jason D. Fernandes

This paper introduces ELXRs, CRISPR-CasX-based epigenetic repressors that use sequential proofreading to enhance specificity and potency by reading chromatin state before DNA methylation.

1 citation

mouseCRISPR screen

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