Joris J. T. H. Roelofs

This study shows that chronic low-concentration PM2.5 exposure after ischemic injury accelerates CKD through mitochondrial dysfunction and lysosomal stress, with nicotinamide reversing some effects.

This study identifies NNMT as a driver of tubular senescence and fibrosis in CKD, showing its association with senescence markers and protective effects when inhibited.

This paper identifies specific macrophage subsets in ANCA-associated glomerulonephritis that drive inflammation and fibrosis, suggesting therapeutic targets.