Loes M. Butter

This study shows that chronic low-concentration PM2.5 exposure after ischemic injury accelerates CKD through mitochondrial dysfunction and lysosomal stress, with nicotinamide reversing some effects.

This study shows that levamisole suppresses B-cell proliferation and antibody production, offering mechanistic insights into its therapeutic use in idiopathic nephrotic syndrome.

This study identifies NNMT as a driver of tubular senescence and fibrosis in CKD, showing its association with senescence markers and protective effects when inhibited.

This study shows that PM2.5 exposure worsens IRI-induced AKI in mice by increasing tubular damage, immune activation, and fibrosis markers.

This paper identifies a selective HDAC1/2 inhibitor, Cmpd60, that rejuvenates multiple organ systems in aged mice through transcriptional effects mimicking genetic longevity interventions.

This study investigates the dual role of PAR4 in renal I/R injury, showing it contributes to renal injury and inflammation while maintaining the filtration barrier.