Aldo Jongejan

The paper uses a 3D CLL spheroid model to study how lymph node microenvironmental signals influence CLL cell phenotypes and drug responses to ibrutinib.

This study evaluates how deconvolution methods for spatial transcriptomics data perform when cell types are missing from reference datasets, finding that performance decreases with the number of missing cell types.

AbSolution enables integrated analysis of sequence-derived features in immune repertoires across datasets and conditions.

This paper identifies specific macrophage subsets in ANCA-associated glomerulonephritis that drive inflammation and fibrosis, suggesting therapeutic targets.

This study identifies distinct monocyte phenotypes and gene expression patterns in ANCA-associated vasculitis serotypes, linking them to cardiovascular risk.

The paper examines microglia nodules in multiple sclerosis and finds they are associated with higher lesion load and specific gene expression changes compared to stroke.

The paper identifies atracurium as an FDA-approved compound that extends lifespan and healthspan in C. elegans by activating the FOXO/DAF-16 longevity pathway through neuromuscular acetylcholine receptor inhibition.

This study shows that Per1 and Per2 are required for the daily rhythm of photoreceptor outer segment phagocytosis, with the RPE driving this process transcriptionally.

This study shows glycine supplementation extends C. elegans lifespan and alters gene expression, with effects dependent on the methionine cycle.