Baktiar O. Karim

The paper develops a perfusion circuit system to preserve tumor microenvironments in 3D patient-derived tumor models for up to 48 hours, enabling complex drug interrogations.

Genetic ablation of Id1 in Tet2-/- mice reduces clonal hematopoiesis by increasing CDKI expression, apoptosis, senescence, and differentiation while decreasing cell growth.

The paper investigates how Angubindin-1 disrupts the blood-tumor barrier by targeting Angulin-1/LSR, enhancing drug permeability and reducing glioma progression.

This study identifies a GC-rich cis element in the ORF75 promoter of KSHV that drives its constitutive expression in endothelial and epithelial cells, contributing to its high expression in Kaposi sarcoma lesions.

This study shows SRSF3 is oncogenic in breast cancer and tumor-suppressive in liver cancer through context-dependent gene regulation.

This study identifies LZK as a therapeutic target in HNSCC by showing its regulation of c-MYC and GOF p53, and demonstrates PROTAC-mediated degradation as a potential treatment.

This study maps the SCLC tumor microenvironment and identifies cancer-associated fibroblasts as key drivers of neuroendocrine state plasticity and poor prognosis.