Steffen Fuchs

The paper identifies NPM1::ALK-derived circular RNAs that promote aggressiveness in ALK-positive anaplastic large cell lymphoma by modulating cytokine signaling and myeloid remodeling.

This study develops a method to detect minimal residual disease in neuroblastoma using ecDNA breakpoints, achieving high sensitivity and specificity in bone marrow samples.

The paper identifies circZBTB46 as a driver of crizotinib resistance in ALK-positive lymphomas and shows its targeting restores drug sensitivity.

This paper shows that high MYCN levels in neuroblastoma reduce L1CAM expression, limiting CAR T cell efficacy, and that inhibiting MYCN with MLN8237 restores L1CAM and enhances CAR T cell activity.