Author

Petra Vlckova

University College LondonORCID 0000-0001-9633-8492Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Christopher J. TapeiD· 3 shared Alistair Wilkinson· 2 shared Aurélie DobriciD· 2 shared Rhianna O’SullivaniD· 2 shared Shauna CrampsieiD· 2 shared Smita KrishnaswamyiD· 2 shared A McCullochiD· 1 shared Ashley Campbell· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersCancer Biology

Christopher J. TapeORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJul 15, 2026

Epithelial Stem Cell Fate Determines Chemoradiotherapy Response in Rectal Cancer

N. Li, Fiza Ishaqwala, Thomas A. Wright…·Christopher J. Tape

This study identifies that epithelial stem cell fate, not DNA damage, determines chemoradiotherapy response in rectal cancer by analyzing patient-derived organoids and using SPARTA to validate findings.

DOI 10.64898/2026.07.15.736775

humanscRNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintJun 18, 2026

Stromal Prostaglandin is a Dominant Spatial Regulator of Cell-fate Plasticity in Colorectal Cancer

Corinne Molyneux, Rhianna O’Sullivan, Eoghan J. Mulholland-Illingworth…·Christopher J. Tape

This study identifies stromal prostaglandin E2 as a key regulator of cell-fate plasticity in colorectal cancer, showing it converts chemosensitive stem cells into chemorefractory, prometastatic cells.

1 citation

humanorganoid / primary culture

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Cancer BiologyEMBO Molecular MedicinePeer-reviewedAug 5, 2024

Chemotherapeutic regulation of the ROS/MondoA-dependent TXNIP/GDF15 axis; and derivation of a new organoid metric as a predictive biomarker

Jinhai Deng, Teng Pan, Dan Wang…·Tony Ng

The paper identifies chemotherapy-induced TXNIP as a negative regulator of GDF15 in CRC, showing its potential as a prognostic biomarker through organoid models.

9 citations

humanproteomics

𝕏 PostBluesky